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HTLV1 Target gene Detail Information

> ACO2 Gene Search Result


Gene Information
Gene Name ACO2
Gene ID 50
Gene Full Name aconitase 2
Gene Alias ICRD; OCA8; OPA9; ACONM; HEL-S-284
Transcripts ENSG00000100412
Virus HTLV1
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q99798
HGNC ID HGNC:118
VEGA ID OTTHUMG00000030544
OMIM ID 100850
String ID 9606.ENSP00000216254
Drugbank ID BE0004504
PharmGKB ID PA24443
Target gene [ACO2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6005297 chr22 58 28 4 90 View
6011668 chr22 20 5 25 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of ACO2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACO2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of ACO2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACO2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of ACO2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACO2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).