HTLV1 Target gene Detail Information

> ACE2 Gene Search Result


Gene Information
Gene Name ACE2
Gene ID 59272
Gene Full Name angiotensin I converting enzyme 2
Gene Alias ACEH
Transcripts ENSG00000130234
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID Q9BYF1
HGNC ID HGNC:13557
VEGA ID OTTHUMG00000021177
OMIM ID 300335
String ID 9606.ENSP00000389326
Drugbank ID BE0000982
PharmGKB ID PA425
Target gene [ACE2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004321 chr21 92 20 7 119 View
6011164 chr21 23 4 27 View
6018589 chr21 8 1 9 View
6021424 chrX 6 6 View
6021425 chrX 6 6 View
6021426 chrX 6 6 View
6021427 chrX 6 6 View
6029032 chr21 1 1 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).