HTLV1 Target gene Detail Information

> ACE2 Gene Search Result

Gene Information

Gene Name	ACE2
Gene ID	59272
Gene Full Name	angiotensin I converting enzyme 2
Gene Alias	ACEH
Transcripts	ENSG00000130234
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q9BYF1
HGNC ID	HGNC:13557
VEGA ID	OTTHUMG00000021177
OMIM ID	300335
String ID	9606.ENSP00000389326
Drugbank ID	BE0000982
PharmGKB ID	PA425

Target gene [ACE2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004321	chr21	92	20	7	119	View
6011164	chr21	23	4		27	View
6018589	chr21	8	1		9	View
6021424	chrX	6			6	View
6021425	chrX	6			6	View
6021426	chrX	6			6	View
6021427	chrX	6			6	View
6029032	chr21	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ACE2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ACE2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).