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HBV Target gene Detail Information

> ACACA Gene Search Result


Gene Information
Gene Name ACACA
Gene ID 31
Gene Full Name acetyl-CoA carboxylase alpha
Gene Alias ACC; ACAC; ACC1; ACCA; ACACAD
Transcripts ENSG00000275176
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Actin filaments;Nucleoli fibrillar center;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q13085
HGNC ID HGNC:84
VEGA ID OTTHUMG00000191242
OMIM ID 200350
String ID 9606.ENSP00000483300
Drugbank ID BE0000626
PharmGKB ID PA24421
Target gene [ACACA] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003208 chr17 59 35 62 156 View
1004809 chr17 18 25 25 68 View
1005056 chr17 15 22 25 62 View
1402687 chr17 18 25 25 68 View
1402688 chr17 15 22 25 62 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ACACA expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ACACA expression: Low -> High
Lollipop of ACACA expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ACACA expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ACACA expression and immune infiltrating cell level correlation result in HBV+ samples
ACACA expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).