HTLV1 Target gene Detail Information

> ABTB2 Gene Search Result

Gene Information

Gene Name	ABTB2
Gene ID	25841
Gene Full Name	ankyrin repeat and BTB domain containing 2
Gene Alias	ABTB2A; BTBD22
Transcripts	ENSG00000166016
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q8N961
HGNC ID	HGNC:23842
VEGA ID	OTTHUMG00000044382
String ID	9606.ENSP00000410157
PharmGKB ID	PA134937734

Target gene [ABTB2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000685	chr11	219	420	344	983	View
6001137	chr11	15	288	268	571	View
6005451	chr11	44	28	15	87	View
6009236	chr11	35	3		38	View
6014904	chr11	10	4	1	15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ABTB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ABTB2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ABTB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ABTB2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ABTB2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
ABTB2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).