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HBV Target gene Detail Information

> ABCB4 Gene Search Result


Gene Information
Gene Name ABCB4
Gene ID 5244
Gene Full Name ATP binding cassette subfamily B member 4
Gene Alias GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
Transcripts ENSG00000005471
Virus HBV
Gene Type protein coding
HPA Location Info Actin filaments;Nucleoplasm;Plasma membrane;Focal adhesion sites;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID P21439
HGNC ID HGNC:45
VEGA ID OTTHUMG00000023396
OMIM ID 171060
String ID 9606.ENSP00000265723
Drugbank ID BE0003641
PharmGKB ID PA268
Target gene [ABCB4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1009748 chr7 4 10 14 View
1402935 chr7 4 10 14 View
1404850 chr7 75 1 5 81 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ABCB4 expression and immune infiltrating cell level correlation result in HBV+ samples
ABCB4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).