HIV Target gene Detail Information

> ABCA7 Gene Search Result

Gene Information

Gene Name	ABCA7
Gene ID	10347
Gene Full Name	ATP binding cassette subfamily A member 7
Gene Alias	AD9; ABCX; ABCA-SSN
Transcripts	ENSG00000064687
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Plasma membrane;Cell Junctions;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q8IZY2
HGNC ID	HGNC:37
VEGA ID	OTTHUMG00000167547
OMIM ID	605414
String ID	9606.ENSP00000263094
PharmGKB ID	PA24382

Target gene [ABCA7] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000424	chr19	231	68	176	475	View
4006686	chr19	23			23	View
4007111	chr19	12	9		21	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ABCA7 expression and immune infiltrating cell level correlation result in HIV+ samples
ABCA7 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ABCA7 expression and immune infiltrating cell level correlation result in HIV+ samples
ABCA7 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).