HIV Target gene Detail Information

> ABCA2 Gene Search Result

Gene Information

Gene Name	ABCA2
Gene ID	20
Gene Full Name	ATP binding cassette subfamily A member 2
Gene Alias	ABC2
Transcripts	ENSG00000107331
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	Q9BZC7
HGNC ID	HGNC:32
VEGA ID	OTTHUMG00000020958
OMIM ID	600047
String ID	9606.ENSP00000344155
PharmGKB ID	PA24377

Target gene [ABCA2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000449	chr9	3	303	151	457	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ABCA2 expression and immune infiltrating cell level correlation result in HIV+ samples
ABCA2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ABCA2 expression and immune infiltrating cell level correlation result in HIV+ samples
ABCA2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).