HTLV1 Target gene Detail Information

> A4GALT Gene Search Result

Gene Information

Gene Name	A4GALT
Gene ID	53947
Gene Full Name	alpha 1,4-galactosyltransferase (P blood group)
Gene Alias	P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1
Transcripts	ENSG00000128274
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted membrane proteins
Uniport_ID	Q9NPC4
HGNC ID	HGNC:18149
VEGA ID	OTTHUMG00000150744
OMIM ID	607922
String ID	9606.ENSP00000384794
PharmGKB ID	PA24359

Target gene [A4GALT] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002874	chr22	70	69	63	202	View
6014244	chr22	7	10		17	View
6021759	chr22	2	1	2	5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of A4GALT expression and immune infiltrating cell level correlation result in HTLV1+ samples
A4GALT expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of A4GALT expression and immune infiltrating cell level correlation result in HTLV1+ samples
A4GALT expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of A4GALT expression and immune infiltrating cell level correlation result in HTLV1+ samples
A4GALT expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).