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HBV Target gene Detail Information

> A2M Gene Search Result


Gene Information
Gene Name A2M
Gene ID 2
Gene Full Name alpha-2-macroglobulin
Gene Alias A2MD; CPAMD5; FWP007; S863-7
Transcripts ENSG00000175899
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Uniport_ID P01023
HGNC ID HGNC:7
VEGA ID OTTHUMG00000150267
OMIM ID 103950
String ID 9606.ENSP00000323929
Drugbank ID BE0000910
PharmGKB ID PA24357
Target gene [A2M] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006071 chr12 30 14 44 View
1006800 chr12 27 7 34 View
1007602 chr12 22 4 26 View
1009992 chr12 7 1 6 14 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of A2M expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
A2M expression: Low -> High
Lollipop of A2M expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of A2M expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of A2M expression and immune infiltrating cell level correlation result in HBV+ samples
A2M expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).