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Mutation Information
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Mutation Site
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Z197K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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BZLF1 |
Literature Information
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PubMed PMID
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9123876
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Published Year
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1997 |
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Journal
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Virology |
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Title
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The bZip dimerization domain of the Epstein-Barr virus BZLF1 (Z) protein mediates lymphoid-specific negative regulation. |
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Author
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Hong Y,Holley-Guthrie E,Kenney S |
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Evidence
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We nowfind that two mutant Z proteins (Z197K/200S and Z200E/225E), which we had reported to be dimerization incompetent, are able to dimerize to Z (although the Z200E/Z225E mutant dimerizes less efficiently than wild-type Z) but no longer bind to p65 (Fig. 1C).
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EBV Mutation Detail Information