HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y768S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp41

Literature Information

PubMed PMID	21569545
Published Year	2011
Journal	Retrovirology
Title	Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity.
Author	Bhakta SJ,Shang L,Prince JL,Claiborne DT,Hunter E
Evidence	Mutagenesis of the first two pins (L765H and Y768S) in the three-pin motif LxxY768xxL, which binds to AP2, at the N-terminus of LLP2 resulted in 62% and 63% the fusogenicity of WT for mutants A and YA, respectively.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation