|
Mutation Information
|
Mutation Site
|
Y712C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp41 |
Literature Information
|
PubMed PMID
|
21569545
|
|
Published Year
|
2011 |
|
Journal
|
Retrovirology |
|
Title
|
Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity. |
|
Author
|
Bhakta SJ,Shang L,Prince JL,Claiborne DT,Hunter E |
|
Evidence
|
The Y712 mutation (Y712C) contributed to at least a 4-fold increase in surface expression for all mutants containing this change.
|
|
|
HIV Mutation Detail Information