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Mutation Information
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Mutation Site
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Y69A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Vif |
Literature Information
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PubMed PMID
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24418540
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Published Year
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2014 |
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Journal
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Virology |
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Title
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Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis. |
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Author
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Matsui Y,Shindo K,Nagata K,Io K,Tada K,Iwai F,Kobayashi M,Kadowaki N,Harris RS,Takaori-Kondo A |
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Evidence
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To test our hypothesis that conserved residues E88 and W89 may be required for CBFβ binding, we generated nine point mutants of Vif, D14A/R15A, W21A, W38A, Y40A, Y69A, G84D, E88A, W89A, and E88A/W89A (Fig. 1A).
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HIV Mutation Detail Information