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Mutation Information
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Mutation Site
|
Y59D |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E7 |
|
Amino acid_Mutation
|
T727G |
|
Genotype/Subtype
|
HPV52 |
|
Viral Reference
|
X74481
|
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
27977741
|
|
Disease
|
Low grade squamous intraepithelial lesion;
High grade squamous intraepithelial lesion;
Cervical intraepithelial neoplasia;
Cervical carcinoma;
Squamous-cell carcinoma
|
|
Published Year
|
2016 |
|
Journal
|
PloS one |
|
Title
|
Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea. |
|
Author
|
Choi YJ,Ki EY,Zhang C,Ho WC,Lee SJ,Jeong MJ,Chan PK,Park JS |
|
Evidence
|
Lineage C also harbored lineage-specific variations (Table 3), of which an E6 nonsynonymous mutation (L83V, concurrent mutations of C348G and G350T) and five E7 nonsynonymous mutations, S52D (concurrent mutations of A706G and G707A), Y55D (T727G), H61Y (C733T), D64N (G742A) and L99R (T848G), showed significant associations with the lineage (P < 0.0001).
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HPV Mutation Detail Information