|
Mutation Information
|
Mutation Site
|
Y54D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
17452980
|
|
Published Year
|
2007 |
|
Journal
|
Oncogene |
|
Title
|
hAda3 regulates p14ARF-induced p53 acetylation and senescence. |
|
Author
|
Sekaric P,Shamanin VA,Luo J,Androphy EJ |
|
Evidence
|
Consistent with these findings, the human papillomavirus 16 E6 mutant Y54D, which selectively targets hAda3 but not p53 for degradation and protects MECs from p14ARF-induced senescence, inhibited p53 acetylation.
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HPV Mutation Detail Information