HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y47D
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tat

Literature Information

PubMed PMID	32824587
Published Year	2020
Journal	International journal of molecular sciences
Title	Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation.
Author	Szojka Z,Mótyán JA,Miczi M,Mahdi M,Tőzsér J
Evidence	While wild-type Tat stimulates the activity of RT, Nullbasic Tat mutations;where the entire basic domain is replaced by Gly and Ala residues, and Y47D substitution, were found to hinder Tat-mediated transactivation, extinguish reverse transcription, and inhibit the activity of Rev.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation