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Mutation Information
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Mutation Site
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Y384G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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LMP1 |
Literature Information
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PubMed PMID
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29134204
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Published Year
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2017 |
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Journal
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mSphere |
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Title
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Latent Membrane Protein 1 Is a Novel Determinant of Epstein-Barr Virus Genome Persistence and Reactivation. |
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Author
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Caves EA,Butch RM,Cook SA,Wasil LR,Chen C,Di YP,Lee N,Shair KHY |
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Evidence
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Deletion of the PXQXT TRAF-binding motif in CTAR1 (ΔPXQXT), but not mutation of the CTAR2 residue (Y384G) critical for NF-κB activation, resulted in a more progressive loss of EBV genomes, stabilizing at a 90% loss by 46 days (Fig. 2a).
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EBV Mutation Detail Information