Mutation Information
Mutation Site
|
Y206C |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Genotype/Subtype
|
D |
Viral Reference
|
X68292.1
|
Country
|
Italy |
Literature Information
PubMed PMID
|
25452041
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2015 |
Journal
|
The Journal of infection |
Title
|
Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection. |
Author
|
Mirabelli C,Surdo M,Van Hemert F,Lian Z,Salpini R,Cento V,Cortese MF,Aragri M,Pollicita M,Alteri C,Bertoli A,Berkhout B,Micheli V,Gubertini G,Santoro MM,Romano S,Visca M,Bernassola M,Longo R,De Sanctis GM,Trimoulet P,Fleury H,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Zhang JM,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V |
Evidence
|
Results: Specific HBsAg-mutations (M197T,-S204N-Y206C/H-F220L) were significantly correlated with serum HBV-DNA <2000 IU/ml (posterior-probability>90%, P < 0.05).
|
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