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Mutation Information
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Mutation Site
|
Y196A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Tax |
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Combined Mutation
|
tax.Y196A+tax.K197S |
Literature Information
|
PubMed PMID
|
8756622
|
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Published Year
|
1996 |
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Journal
|
Molecular and cellular biology |
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Title
|
Interaction of the human T-cell lymphotropic virus type 1 tax transactivator with transcription factor IIA. |
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Author
|
Clemens KE,Piras G,Radonovich MF,Choi KS,Duvall JF,DeJong J,Roeder R,Brady JN |
|
Evidence
|
Importantly, two previously characterized mutants with point mutations in Tax, M32 (Y196A, K197S) and M41 (H287A, P288S), which were shown to be defective in Tax-activated transcription were unable to interact with TFIIA in this assay.
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HTLV1 Mutation Detail Information