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Mutation Information
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Mutation Site
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Y188L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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32183488
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Published Year
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2020 |
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Journal
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Molecules (Basel, Switzerland) |
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Title
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2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication. |
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Author
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Corona A,Onnis V,Del Vecchio C,Esposito F,Cheng YC,Tramontano E |
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Evidence
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The allosteric inhibition of the polymerase function of RT was achieved in the 1990s with non-nucleoside inhibitors (NNRTI) that are still in the first-line therapy, although displaying a fairly low genetic barrier to selection of resistant variants, among which K103N, Y181C, and Y188L are the most common.
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HIV Mutation Detail Information