HIV Mutation Detail Information

> Y188L Search Result


Mutation Information
Mutation Site Y188L
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Literature Information
PubMed PMID 32006797
Published Year 2020
Journal Bioorganic chemistry
Title Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Author Sang Y,Pannecouque C,De Clercq E,Zhuang C,Chen F
Evidence Compound 51 displayed exceptionally potent activity against WT virus (EC50 = 6 nM) and several mutant strains (L100I, EC50 = 8 nM, K103N, EC50 = 6 nM, Y181C, EC50 = 26 nM, Y188L, EC50 = 122 nM, E138K, EC50 = 26 nM).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation