HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y188L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Country	Thailand

Literature Information

PubMed PMID	22132100
Disease	HIV infection/AIDS
Published Year	2011
Journal	PloS one
Title	Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis.
Author	Ngo-Giang-Huong N,Jourdain G,Amzal B,Sang-a-gad P,Lertkoonalak R,Eiamsirikit N,Tansuphasawasdikul S,Buranawanitchakorn Y,Yutthakasemsunt N,Mekviwattanawong S,McIntosh K,Lallemant M,Program for HIV Prevention and Treatment (PHPT) study group.
Evidence	When adjusted for the effects of failure duration, viral load and NRTI backbone, the analysis, presented in Figure 2A, showed that the use of a nevirapine-based regimen was associated with significantly increased risks of mutations G190A (the posterior probability of G190A occurring on a nevirapine-based regimen or PP[OR<1] was >99%), Y188L (PP[OR<1] = 97.5%), Y181C (PP[OR<1]>99%), K101E (PP[OR<1]>99%), Y115F (PP[OR<1]>99%) and K65R PP[OR<1]>99%) as compared with an efavirenz-based treatment.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation