HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y188H
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	C
Relevant Drug	NNRTIs
Country	South Africa

Literature Information

PubMed PMID	22293461
Disease	HIV infection/AIDS
Published Year	2012
Journal	Antiviral therapy
Title	Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy.
Author	Wallis CL,Papathanasopolous MA,Fox M,Conradie F,Ive P,Orrell C,Zeinecker J,Sanne I,Wood R,McIntyre J,Stevens W,CIPRA-SA project 1 study team.
Evidence	All three subjects failing the NLF-based regimen had the M184V mutation and the two with prior sdNVP exposure also had NNRTIs mutations (K103N, V106M n=1; K103N, Y188H n=1).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation