|
Mutation Information
|
Mutation Site
|
Y188C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
lopinavir (LPV);ritonavir |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
22293461
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral therapy |
|
Title
|
Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy. |
|
Author
|
Wallis CL,Papathanasopolous MA,Fox M,Conradie F,Ive P,Orrell C,Zeinecker J,Sanne I,Wood R,McIntyre J,Stevens W,CIPRA-SA project 1 study team. |
|
Evidence
|
Of the remaining nine participants failing a LPV/r regimen, M184V was observed in one subject and K103N, V106A and Y188C in another female subject (with no previous sdNVP exposure reported).
|
|
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HIV Mutation Detail Information