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Mutation Information
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Mutation Site
|
Y181I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B;CRF01_AE;CRF08_BC;CRF07_BC |
|
Relevant Drug
|
lamivudine (LAM);efavirenz (EFV);nevirapine (NPV) |
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Country
|
China |
Literature Information
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PubMed PMID
|
31922125
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2020 |
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Journal
|
EClinicalMedicine |
|
Title
|
Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017). |
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Author
|
Zuo L,Liu K,Liu H,Hu Y,Zhang Z,Qin J,Xu Q,Peng K,Jin X,Wang JH,Zhang C |
|
Evidence
|
One NRTI-associated (M184V/I) and three NNRTI-associated (K103N/S, Y181C/I and G190A/S) mutations had high percentages in ART-naive and ART-treated individuals, and these mutations conferred high-level resistance to 3TC, EFV and/or NVP.
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HIV Mutation Detail Information