|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
33126458
|
|
Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
|
Title
|
Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential. |
|
Author
|
Nahar L,Talukdar AD,Nath D,Nath S,Mehan A,Ismail FMD,Sarker SD |
|
Evidence
|
Furthermore, this pyranocoumarin (1) showed activity against HIV with the two most common NNRTI-related mutations, K103N and Y181C, and was found to select for a mutation that does not cause cross-resistance with any other NNRTIs under investigation.
|
|
|
HIV Mutation Detail Information