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Mutation Information
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Mutation Site
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Y181C |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Viral Reference
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K03455.1
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Relevant Drug
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NNRTIs |
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Country
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Southeast China |
Literature Information
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PubMed PMID
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32972239
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Disease
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HIV infection/AIDS
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Published Year
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2021 |
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Journal
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AIDS research and human retroviruses |
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Title
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Molecular Epidemiology of HIV-1 in Jiangsu Province, Southeast China: Genotypes and HIV-1 Transmission Networks Among Newly Diagnosed Men Having Sex with Men in 2017. |
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Author
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Yin Y,Zhou Y,Lu J,Liu X,Shi L,Fu G,Huan X,Fang S,Liu Y,Wang B,Ding J |
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Evidence
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According to the Surveillance Drug Resistance Mutations (SDRMs) list published in 2009,16 the proportion of 767 pol sequences with SDRMs was 2.74% (n = 21), including 6 samples with NRTI mutations (M41L, M184I, T215S), 13 samples with NNRTI mutations (K101E, K103S, K103N, V106A, V106M, Y181C, G190A, G190S), and 4 samples with PIs mutations (M46I, G73S, N88S). Drug resistance analysis showed that more than half of the participants had high or medium resistance to Nevirapine (NVP) and Efavurebz (EFV). Detailed information is shown in Supplementary Table S1.
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HIV Mutation Detail Information