|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
32925358
|
|
Published Year
|
2020 |
|
Journal
|
Journal of acquired immune deficiency syndromes (1999) |
|
Title
|
Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development. |
|
Author
|
Martin EA,Lai MT,Ngo W,Feng M,Graham D,Hazuda DJ,Kumar S,Hwang C,Sklar P,Asante-Appiah E |
|
Evidence
|
DOR was rationally designed to address limitations associated with other approved NNRTIs, particularly resistance from common NNRTI resistance-associated mutants containing K103N, Y181C, or G190A reverse transcriptase substitutions.
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HIV Mutation Detail Information