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Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.Y181C+rt.K103N |
Literature Information
|
PubMed PMID
|
32631509
|
|
Published Year
|
2020 |
|
Journal
|
Bioorganic & medicinal chemistry letters |
|
Title
|
Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. |
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Author
|
Sun S,Huang B,Li Z,Wang Z,Sun L,Gao P,Kang D,Chen CH,Lee KH,Daelemans D,De Clercq E,Pannecouque C,Zhan P,Liu X |
|
Evidence
|
In addition, it showed moderate inhibitory potency (EC50 = 1.329 muM) against the HIV-1 K103N/Y181C double mutant strain (MT-4 cells).
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HIV Mutation Detail Information