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Mutation Information
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Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM);tenofovir (TDF);efavirenz (EFV) |
|
Country
|
urban Malawi |
Literature Information
|
PubMed PMID
|
32434561
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and therapy |
|
Title
|
Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi. |
|
Author
|
Neuhann F,de Forest A,Heger E,Nhlema A,Scheller C,Kaiser R,Steffen HM,Tweya H,Fätkenheuer G,Phiri S |
|
Evidence
|
The prevalence of intermediate or high level NNRTI- PDR was 11.2% (22/197). The most common mutation was K103N (5.6%, 11/197), followed by Y181C (3.6%, 7/197). In one case, we detected an NRTI resistance mutation (M184V), in combination with multiple NNRTI resistance mutations.
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HIV Mutation Detail Information