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Mutation Information
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Mutation Site
|
Y181C |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
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nevirapine (NPV) |
Literature Information
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PubMed PMID
|
32235557
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Published Year
|
2020 |
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Journal
|
Molecules (Basel, Switzerland) |
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Title
|
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs. |
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Author
|
Li TT,Pannecouque C,De Clercq E,Zhuang CL,Chen FE |
|
Evidence
|
Docking of B4 with K103N + Y181C predicted that several common features ("U" binding conformation, hydrogen bonds, and pi-pi stacking interactions) would be lost, which might contribute to the decrease in antiviral activity of compound B4 against the HIV-1 double mutants K103N + Y181C.
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HIV Mutation Detail Information