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Mutation Information
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Mutation Site
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Y181C |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
|
PubMed PMID
|
32140396
|
|
Published Year
|
2020 |
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Journal
|
Acta pharmaceutica Sinica. B |
|
Title
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Synthesis and biological evaluation of a series of 2-(((5-akly/aryl-1H-pyrazol-3-yl)methyl)thio)-5-alkyl-6-(cyclohexylmethyl)-pyrimidin-4(3H)-ones as potential HIV-1 inhibitors. |
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Author
|
Wu Y,Tang C,Rui R,Yang L,Ding W,Wang J,Li Y,Lai CC,Wang Y,Luo R,Xiao W,Zhang H,Zheng Y,He Y |
|
Evidence
|
On the other hand, it was observed that those two compounds were less effective with EC50 values of 2.77 and 4.87 mumol/L for HIV-1A17 (K103N + Y181C).
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HIV Mutation Detail Information