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Mutation Information
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Mutation Site
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Y181C |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
|
32111013
|
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Published Year
|
2020 |
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Journal
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Molecules (Basel, Switzerland) |
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Title
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Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy. |
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Author
|
Lei Y,Han S,Yang Y,Pannecouque C,De Clercq E,Zhuang C,Chen FE |
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Evidence
|
These compounds were also tested in the MT-4 cells for their activities against the single mutant (L100I, E138K, Y181C, K103N, Y188L) and double RT mutant (K103N + Y181C, F227L + V106A) HIV-1 strains.
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HIV Mutation Detail Information