|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
nevirapine (NPV);etravirine (ETR);doravirine (DOR) |
Literature Information
|
PubMed PMID
|
31370888
|
|
Published Year
|
2019 |
|
Journal
|
Infectious diseases of poverty |
|
Title
|
The urgent need for more potent antiretroviral therapy in low-income countries to achieve UNAIDS 90-90-90 and complete eradication of AIDS by 2030. |
|
Author
|
Ndashimye E,Arts EJ |
|
Evidence
|
However, the high HIVDR due to Y181C after NVP exposure necessitates genotypic test before use of ETR as salvage therapy. Doravirine being tested in once daily doravirine/3TC/TDF combination, is more tolerable, has high efficacy, and activity against viruses with resistant mutations K103 N and Y181C.
|
|
|
HIV Mutation Detail Information