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Mutation Information
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Mutation Site
|
Y181C |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NNRTIs;NRTIs |
Literature Information
|
PubMed PMID
|
27267005
|
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Published Year
|
2016 |
|
Journal
|
European journal of medicinal chemistry |
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Title
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Structural optimization of pyridine-type DAPY derivatives to exploit the tolerant regions of the NNRTI binding pocket. |
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Author
|
Chen W,Zhan P,Daelemans D,Yang J,Huang B,De Clercq E,Pannecouque C,Liu X |
|
Evidence
|
Additionally, compounds I-8c2 and I-8c3 showed moderate activity against NNRTI resistant strains baring mutations K103N and Y181C with EC50 values of 6.2 μM and 6.8 μM, respectively.
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HIV Mutation Detail Information