|
Mutation Information
|
Mutation Site
|
Y181C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Country
|
Italy |
Literature Information
|
PubMed PMID
|
11737863
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2001 |
|
Journal
|
BMC microbiology |
|
Title
|
Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients. |
|
Author
|
Re MC,Monari P,Bon I,Gibellini D,Vitone F,Borderi M,La Placa M |
|
Evidence
|
As expected, the presence of mutations associated with resistance to non nucleoside reverse transcriptase inhibitors (NNRTIs), only revealed by sequencing analysis showed VI 081 (associated with a reduced drug sensitivity to efavirenz plus nevirapine), V118I (associated with moderate phenotypic lamivudine resistance) and the presence of K103N (key mutation for all the NNRIs) plus Y181C (with variable effects on susceptibility to efavirenz, besides resistance to nevirapine).
|
|
|
HIV Mutation Detail Information