HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y177F
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Immune Escape	Y

Literature Information

PubMed PMID	30538178
Published Year	2018
Journal	mBio
Title	Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.
Author	Guzzo C,Zhang P,Liu Q,Kwon AL,Uddin F,Wells AI,Schmeisser H,Cimbro R,Huang J,Doria-Rose N,Schmidt SD,Dolan MA,Connors M,Mascola JR,Lusso P
Evidence	Thus, the double-alanine mutant showed the greatest gain in neutralization sensitivity, followed by the Y177A single mutant, while the double-phenylalanine mutant and the Y173A and Y177F single mutants showed an intermediate sensitivity; in contrast, the Y173F single mutant had the same sensitivity as the WT (Fig. 5A).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation