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Mutation Information
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Mutation Site
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Y177A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
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Combined Mutation
|
gp120.Y177A+gp120.Y173A |
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Genotype/Subtype
|
B |
|
Immune Escape
|
Y |
Literature Information
|
PubMed PMID
|
30538178
|
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Published Year
|
2018 |
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Journal
|
mBio |
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Title
|
Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation. |
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Author
|
Guzzo C,Zhang P,Liu Q,Kwon AL,Uddin F,Wells AI,Schmeisser H,Cimbro R,Huang J,Doria-Rose N,Schmidt SD,Dolan MA,Connors M,Mascola JR,Lusso P |
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Evidence
|
To confirm the role of the V2 loop tyrosines in maintaining the HIV-1 trimer in a closed, antibody-protected configuration, we tested the sensitivity of the double-alanine mutant HIV-1 BaL Y173A Y177A to neutralization by a larger panel of weakly or nonneutralizing antibodies directed against diverse Env antigenic regions, including non-glycan-dependent V2 loop epitopes, the tip of the V3 loop, the CD4-BS, and the coreceptor-binding site.
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HIV Mutation Detail Information