HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y173A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Combined Mutation	gp120.Y177A+gp120.Y173A
Genotype/Subtype	B
Immune Escape	Y

Literature Information

PubMed PMID	30538178
Published Year	2018
Journal	mBio
Title	Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation.
Author	Guzzo C,Zhang P,Liu Q,Kwon AL,Uddin F,Wells AI,Schmeisser H,Cimbro R,Huang J,Doria-Rose N,Schmidt SD,Dolan MA,Connors M,Mascola JR,Lusso P
Evidence	To confirm the role of the V2 loop tyrosines in maintaining the HIV-1 trimer in a closed, antibody-protected configuration, we tested the sensitivity of the double-alanine mutant HIV-1 BaL Y173A Y177A to neutralization by a larger panel of weakly or nonneutralizing antibodies directed against diverse Env antigenic regions, including non-glycan-dependent V2 loop epitopes, the tip of the V3 loop, the CD4-BS, and the coreceptor-binding site.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation