|
Mutation Information
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Mutation Site
|
Y143R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
INSTIs |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
33632139
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2021 |
|
Journal
|
BMC infectious diseases |
|
Title
|
Increased acquired protease inhibitor drug resistance mutations in minor HIV-1 quasispecies from infected patients suspected of failing on national second-line therapy in South Africa. |
|
Author
|
Obasa AE,Ambikan AT,Gupta S,Neogi U,Jacobs GB |
|
Evidence
|
Despite no mention of use of any INIs by the clinical reports, three patient sequences had the Y143R mutation in major viral quasispecies and one in minor viral quasispecies, which confers resistance to raltegravir (RAL).
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HIV Mutation Detail Information