|
Mutation Information
|
Mutation Site
|
Y143R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
Q76353
|
|
Relevant Drug
|
raltegravir (RAL) |
Literature Information
|
PubMed PMID
|
31551948
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence. |
|
Author
|
Machado LA,Gomes MFDC,Guimarães ACR |
|
Evidence
|
The co-occurrence network revealed that the major resistance pathways N155H and Q148HR share more mutations with each other than with the Y143R pathway, this observation corroborates the fact that the N155H pathway is most commonly converted into Q148HRK than into Y143RCH pathway in patients' isolates.
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HIV Mutation Detail Information