|
Mutation Information
|
Mutation Site
|
Y143R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
INSTIs |
|
Country
|
Italian |
Literature Information
|
PubMed PMID
|
31330378
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Journal of global antimicrobial resistance |
|
Title
|
Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors. |
|
Author
|
Scutari R,Alteri C,Vicenti I,Di Carlo D,Zuccaro V,Incardona F,Borghi V,Bezenchek A,Andreoni M,Antinori A,Perno CF,Cascio A,De Luca A,Zazzi M,Santoro MM,ARCA (Antiviral Response Cohort Analysis) Study Group. |
|
Evidence
|
The major INSTI-RMs that more frequently emerged were: N155H (17.8%), G140S (8.4%), Y143R (7.5%), Q148H (6.5%), and Y143C (4.7%).
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HIV Mutation Detail Information