HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y143K
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	US

Literature Information

PubMed PMID	31617907
Disease	HIV infection/AIDS
Published Year	2020
Journal	The Journal of antimicrobial chemotherapy
Title	Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.
Author	Tzou PL,Rhee SY,Descamps D,Clutter DS,Hare B,Mor O,Grude M,Parkin N,Jordan MR,Bertagnolio S,Schapiro JM,Harrigan PR,Geretti AM,Marcelin AG,Shafer RW,WHO HIVResNet Working Groups.
Evidence	Two of the eight polymorphic mutations (A49P and G163K) and 14 of the 23 very rare mutations (L74F, E92V, Y143A/G/K, P145S, Q146I/L/P, V151A/L, S153Y and N155S/T) also had a regression coefficient ≥0.5 log10.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation