HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y143H
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	Taiwan(China)

Literature Information

PubMed PMID	33364799
Disease	HIV infection/AIDS
Published Year	2020
Journal	Infection and drug resistance
Title	Prevalence of HIV-1 Integrase Strand Transfer Inhibitor Resistance in Treatment-Naïve Voluntary Counselling and Testing Clients by Population Sequencing and Illumina Next-Generation Sequencing in Taiwan.
Author	Tsai HC,Chen IT,Tsai KW,Lee SS,Chen YS
Evidence	Of the 38 patients diagnosed in 2017 who had both NGS and population sequencing data, none had INSTI resistance-associated mutations by population sequencing;however, NGS detected four more INSTI resistance-associated mutations with low frequencies (G163R 3.25%, S153F 3.21%, S153Y 1.36% and Y143H 2.06%).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation