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Mutation Information
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Mutation Site
|
Y143C |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
IN |
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Relevant Drug
|
INSTIs |
|
Country
|
Italy |
Literature Information
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PubMed PMID
|
33480094
|
|
Disease
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HIV infection/AIDS
|
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Published Year
|
2021 |
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Journal
|
HIV medicine |
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Title
|
Virological response and resistance profile in highly treatment-experienced HIV-1-infected patients switching to dolutegravir plus boosted darunavir in clinical practice. |
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Author
|
Armenia D,Bouba Y,Gagliardini R,Fabeni L,Borghi V,Berno G,Vergori A,Cicalini S,Mussini C,Antinori A,Ceccherini-Silberstein F,Perno CF,Santoro MM |
|
Evidence
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Among 13 non-responding patients for whom a genotypic resistance test result at failure was available, only two (15.4%) accumulated further resistance in integrase (Y143C/H/R; S147G and N155H) and protease (V32I, L33F, I54L).
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HIV Mutation Detail Information