|
Mutation Information
|
Mutation Site
|
Y143C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
bictegravir (BIC);dolutegravir (DTG) |
|
Country
|
Africa |
Literature Information
|
PubMed PMID
|
31830799
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
AIDS research and human retroviruses |
|
Title
|
HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon. |
|
Author
|
Mikasi SG,Gichana JO,Van der Walt C,Brado D,Obasa AE,Njenda D,Messembe M,Lyonga E,Assoumou O,Cloete R,Ikomey GM,Jacobs GB |
|
Evidence
|
A total of 18.9% (n = 7/37) of the sequences had RAMs, with only 5.4% (n = 2/37) having major RAMs (Y143R/C/D/G and P145S), against INSTIs.
|
|
|
HIV Mutation Detail Information