|
Mutation Information
|
Mutation Site
|
Y143C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Viral Reference
|
Q76353
|
|
Relevant Drug
|
raltegravir (RAL) |
Literature Information
|
PubMed PMID
|
31551948
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Frontiers in microbiology |
|
Title
|
Raltegravir-Induced Adaptations of the HIV-1 Integrase: Analysis of Structure, Variability, and Mutation Co-occurrence. |
|
Author
|
Machado LA,Gomes MFDC,Guimarães ACR |
|
Evidence
|
Curiously, four isolates showed mutations related to more than one of the three main resistance pathways: two from Italy, one with both N155H and Y143R and another with Q148H and Y143H;one from Canada with N155H and Y143C;and one from France with N155H and Q148R.
|
|
|
HIV Mutation Detail Information