HIV Mutation Detail Information

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Mutation Information

Mutation Site	Y143C
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	raltegravir (RAL);etravirine(ETR);darunavir (DRV);ritonavir;enfuvirtide (T20);tenofovir (TDF);emtricitabine (FTC);elvitegravir (EVG)
Country	France

Literature Information

PubMed PMID	20436677
Disease	HIV infection/AIDS
Published Year	2010
Journal	PloS one
Title	The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.
Author	Reigadas S,Anies G,Masquelier B,Calmels C,Stuyver LJ,Parissi V,Fleury H,Andreola ML
Evidence	The HIV-1 Integrase Mutations Y143C/R Are an Alternative Pathway for Resistance to Raltegravir and Impact the Enzyme FunctionsResistance to HIV-1 integrase (IN) inhibitor raltegravir (RAL), is encoded by mutations in the IN region of the pol gene.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation