|
Mutation Information
|
Mutation Site
|
Y143C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
Literature Information
|
PubMed PMID
|
18687142
|
|
Published Year
|
2008 |
|
Journal
|
Retrovirology |
|
Title
|
Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors. |
|
Author
|
Rhee SY,Liu TF,Kiuchi M,Zioni R,Gifford RJ,Holmes SP,Shafer RW |
|
Evidence
|
Nearly all INI-resistance mutations known to directly reduce HIV-1 susceptibility were nonpolymorphic including H51Y, T66I, E92Q, F121Y, G140S, Y143C/H/R, Q146P, S147G, Q148H/R/K, S153Y, N155H/S, and R263K.
|
|
|
HIV Mutation Detail Information