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Mutation Information
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Mutation Site
|
Y138E |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E2 |
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Genotype/Subtype
|
HPV31 |
Literature Information
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PubMed PMID
|
30842331
|
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Published Year
|
2019 |
|
Journal
|
Journal of virology |
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Title
|
Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication. |
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Author
|
DeSmet M,Jose L,Isaq N,Androphy EJ |
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Evidence
|
The tyrosine to glutamic acid (E) mutant Y138E, which can mimic phosphotyrosine, failed to induce transient DNA replication, although it maintained the ability to bind and localize the viral DNA helicase E1 to the viral origin.
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HPV Mutation Detail Information